In a mysterious global-event, all of the Alex's (Alexanders, Als, Alexas, Alexandrias, Lexis, etc.) disappear from the face of the earth. Dealing with the fallout of the loss of their roommate, and the only real connection between them, three should-be friends and living companions face a year of change, adjustment, conspiracy, and love. The Last Day of the Alex's is about what ties us together, and how we face a world of sudden change.