Inspired by real events from the early days of American animation, Osgood Rex is a traditional Greek Tragedy from a cartoon's eye view. Eckhart Unger, creator of the popular "Osgood The Scrappy Squirrel" cartoons, finds he must leave behind his prize creation and start from scratch when an unscrupulous producer steals the rights to the character out from under him. Meanwhile, in the cartoon world, Osgood discovers that his Creator has abandoned him into the hands of lesser gods, and struggles to figure out what he did to deserve such a fate, and how he might reverse it.